Endocrine Abstracts

Introduction: Thyroid disease is associated with cardiovascular disease and many cardiovascular risk factors cluster within the metabolic syndrome. It could therefore be hypothesised that thyroid function is associated with the metabolic syndrome.Aim of the study: To investigate the relationship of thyroid function -in the euthyroid range- with serum lipid concentrations and with insulin resistance.Methods: 2703 adult inhabitants o...

Objective: Many studies suggest that thyroid function modifies the process of healthy aging in humans. However, both a progressive increase and decrease of TSH with advancing age have been reported. The discrepancy may lie in the iodine intake in the population under, since low iodine intake results in an inverse association of TSH with age, while high iodine intake results in a positive association. We aimed to investigate whether FT4, FT3 and FT3</...

Objective: Psychopathology and maladaptive personality traits are often observed during the active phase of Cushing’s disease (CD). We hypothesized that patients with long-term cure of CD show persistent psychopathology and maladaptive personality traits.Aim: To evaluate psychopathology and personality traits in patients with long-term cure of CD.Patients and methods: We included 67 patients cured of CD (15% males, mean age 53...

Background: Although it has been conceived that type 2 diabetes mellitus (DM2) is associated with increased myocardial triglyceride (TG) accumulation, it is unknown whether this can be influenced by modifying plasma non-esterified fatty acids (NEFA) levels. We therefore determined in uncomplicated DM2 whether modifications in plasma NEFA influence myocardial TG content and myocardial function.Research design and methods: Myocardial TG content and left ve...

Introduction: Presence of thyroid peroxidase antibodies (TPOAbs) may be a marker of future thyroid failure. However, prospective studies in a euthyroid population have not been performed.Aim of the study: To prospectively investigate the relationship between presence and levels of TPOAbs and incident hypothyroidism in euthyroid subjects in the general population.Study population: The database used for this study consisted of a rand...

Introduction: Thyroid disease, both clinical and subclinical, is a common disorder. Various studies, however, differ in reported prevalences of abnormal thyroid function.Aim of the study: To investigate 1. the prevalence of abnormal thyroid function and anti-thyroidperoxidase antibodies (TPOab) in a random sample of the inhabitants of a middle-sized city in the Netherlands; 2. the relationship of the presence of TPOab with TSH concentration in the euthyr...

Aim: Patients with autoimmune thyroid disease (AITD) or type 1 diabetes (T1DM) are prone to develop other autoimmune diseases. This has led to the concept of autoimmune polyglandular syndromes (APS). It has been proposed that AITD and type 1 diabetes are both part of the same APS (subtype 2). This would imply that they associate with the same diseases. We evaluated whether the clustering of autoimmune antibodies differs between AITD and T1DM.Methods: Ant...

Introduction: Overall and abdominal obesity are both well-established risk factors of vitamin D deficiency. However, it is unclear which fat depot is most strongly related to serum 25-hydroxyvitamin D (25(OH)D) concentrations.Objective: This study aims to distinguish specific contributions of total body fat, abdominal subcutaneous adipose tissue (aSAT), visceral adipose tissue (VAT) and hepatic fat on 25(OH)D concentrations.Methods...

Background: Turner syndrome (TS) is a rare genetic developmental disorder characterized by gonadal dysfunction, short stature and heart defects, among others. Women with TS often suffer from severe fatigue, for which they are typically referred to endocrinologists. The diagnostic work-up is generally time-consuming and invasive, but it rarely solves the problem. To prevent the personal and financial burden of unnecessary diagnostic procedures, it is crucial to understand fatig...

Background: Patients with long-term remission of Cushing’s disease (CD) demonstrate residual psychological complaints. At present, it is not known how previous exposure to hypercortisolism affects psychological functioning in the long-term. In foregoing Magnetic Resonance Imaging (MRI) studies, abnormalities of brain structure and resting-state connectivity were demonstrated in patients with long-term remission of CD. However, no data are available on functional alteratio...